Metadate CD

(methylphenidate CD)
Full Prescribing Information
DailyMed Drug Information
Forms/Strengths
Capsules: 10 mg, 20 mg, 30 mg, 40 mg, 50 mg, and 60 mg
Dosing
Age: ≥ 6 y/o
Onset: ~ 30-60 min
Duration: 8-12 hours
Release Profile: 30% IR, 70% ER
Considerations: The capsule can be opened, and beads can be swallowed with applesauce. Take orally once daily in the morning, preferably before breakfast.
Initial Dose: 20 mg
Titration: 10-20 mg weekly
Max Dose: 60 mg/day 
Quick Facts
Blocks dopamine/norepinephrine reuptake; enhances focus, attention, impulse control
Extended-release methylphenidate capsule with biphasic release: immediate and delayed
Immediate portion for rapid onset; delayed portion for sustained effect and optimized plasma levels
Common side effects: decreased appetite, insomnia, headache, stomach upset
Indications
 ADHD (ICD-10: F90.0)
Off-Label Uses
N/A 
How to Take
Take once daily in the morning to minimize the risk of insomnia.
Can be taken with or without food; high-fat meals may delay absorption.
Swallow the capsule whole; do not crush or chew.
If needed, the capsule may be opened and sprinkled on applesauce—consume immediately without chewing.
Side Effects
Common: Anorexia, insomnia, headache, abdominal pain.
Serious: Cardiovascular events, psychiatric adverse reactions, growth suppression, priapism, peripheral vasculopathy
Monitoring / Labs
Cardiovascular: Baseline and routine monitoring of heart rate and blood pressure.
Growth in Pediatrics: Regular monitoring of height and weight to detect growth suppression.
Psychiatric Symptoms: Observe for mood changes, anxiety, or psychosis.
Abuse Potential: Monitor for misuse or diversion.
Education
When to Call the Doctor:
Severe mood changes, aggression, or suicidal thoughts.
Chest pain, rapid heartbeat, shortness of breath (cardiovascular concerns).
Uncontrolled movements, tics, or worsening anxiety.
Numbness, coldness, or color changes in fingers or toes (circulatory issues).
Unexplained weight loss or delayed growth in pediatric patients.
Safety Tips:
Monitor blood pressure and heart rate, especially in patients with cardiovascular risk.
Use caution in patients with anxiety, bipolar disorder, or psychosis, as symptoms may worsen.
Avoid caffeine and other stimulants, which may amplify side effects.
Ensure adequate hydration and nutrition, as appetite suppression is common.
Tapering may be required if discontinuing after long-term use.
Parent Tips for Pediatric Patients:
Encourage a nutrient-dense diet to counteract appetite suppression.
Administer in the morning before school for optimal effect.
Monitor school performance and behavioral changes.
Observe for sleep disturbances; adjust timing if necessary.
Communicate regularly with teachers and caregivers about medication effects.
Additional Information
Contraindications:
Hypersensitivity to methylphenidate or formulation components.
Use within 14 days of MAOI therapy (risk of hypertensive crisis).
Symptomatic cardiovascular disease, moderate-to-severe hypertension, hyperthyroidism, glaucoma.
History of substance use disorder, unless benefits outweigh risks.
Pregnancy:
Category C; use only if benefits outweigh risks.
May cause neonatal withdrawal symptoms or low birth weight.
Lactation:
Excreted in breast milk; not recommended due to potential infant exposure.
Drug Interactions:
Serotonergic drugs (e.g., SSRIs, SNRIs, MAOIs) increase serotonin syndrome risk.
Acidifying agents (e.g., ascorbic acid) may reduce drug absorption.
Alkalinizing agents (e.g., sodium bicarbonate) may increase methylphenidate levels.
May potentiate hypertensive effects of certain medications (e.g., decongestants, beta-agonists).