Onyda XR

(generic) 

 

 

 

 Full Prescribing Information 

 DailyMed Drug Information 

 

 

 

 

 Forms/Strengths 

 

 Liquid (organe flavored):  0.1 mg/mL 

 

 

 Dosing 

 

 Age: ≥ 6 y/o 

 Onset: 60-90 min 

 Duration: 12-24 hours 

 Considerations: Orange flavored; Monitor for hypotension, bradycardia, and sedation. Titrate slowly. 

 Initial Dose: 0.1 mg orally once daily at bedtime 

 Titration: Increase by 0.1 mg weekly 

 Max Dose: 0.4 mg once daily 

 

 For patients switching from another clonidine product, discontinue that treatment, and titrate with ONYDA XR using the titration schedule 

 

 Quick Facts 

 

 Increases synaptic dopamine and norepinephrine via presynaptic release and reuptake inhibition 

 Enhances focus, attention, and impulse control 

 Extended-release formulation with dual-phase release for rapid onset and sustained control 

 Unique delivery system provides consistent plasma levels throughout the day 

 Common side effects: decreased appetite, insomnia, headache, gastrointestinal discomfort 

 

 

 Indications 

 

   ADHD (ICD-10: F90.0) 

 

 

 Off-Label Uses 

 

 N/A 

 

 

 How to Take 

 

 Take once daily at bedtime to minimize daytime sedation. 

 Administer orally as a suspension ; shake the bottle gently for at least 10 seconds before each use to ensure proper mixing. 

 Use the provided oral dosing dispenser for accurate measurement; do not use household spoons. 

 Can be taken with or without food , but maintain consistency in relation to meals to ensure stable absorption. 

 If a dose is missed , skip that dose and take the next dose as scheduled; do not double up. 

 Do not abruptly discontinue ; tapering may be required to prevent rebound hypertension . 

 

 

 Side Effects 

 

 Common: Somnolence, fatigue, irritability, headache, abdominal pain, constipation, dry mouth 

 Serious: Hypotension, bradycardia, rebound hypertension, allergic reactions 

 

 

 Monitoring / Labs 

 

 Cardiovascular : Baseline and routine monitoring of heart rate and blood pressure. 

 Growth in Pediatrics : Regular monitoring of height and weight to detect growth suppression. 

 Psychiatric Symptoms : Observe for mood changes, anxiety, or psychosis. 

 Abuse Potential : Monitor for misuse or diversion. 

 

 

 Education 

 

 

 When to Call the Doctor: 

 

 Severe dizziness, fainting, or low blood pressure . 

 Slow or irregular heart rate. 

 Excessive drowsiness or difficulty waking. 

 Mood changes, depression, or unusual behavior. 

 Severe headache, blurred vision, or confusion ( possible hypertensive rebound if stopped abruptly ). 

 

 

 

 Safety Tips: 

 

 Monitor blood pressure and heart rate regularly. 

 Avoid alcohol and sedatives , which may enhance drowsiness. 

 Rise slowly from sitting or lying positions to prevent dizziness. 

 Use caution when driving or operating heavy machinery due to possible sedation. 

 Taper gradually when discontinuing to avoid withdrawal symptoms. 

 

 

 

 Parent Tips for Pediatric Patients: 

 

 May cause daytime drowsiness ; administering at bedtime helps minimize this effect. 

 Monitor for irritability, mood swings, or behavioral changes . 

 Encourage hydration and balanced nutrition to minimize side effects. 

 Ensure children do not engage in high-risk activities (e.g., swimming, biking) if excessively drowsy . 

 Store in child-proof packaging to prevent accidental overdose. 

 

 

 

 

 Additional Information 

 

 

 Contraindications: 

 

 Hypersensitivity to clonidine or formulation components. 

 Use with caution in patients with severe heart disease, bradycardia, or hypotension . 

 

 

 

 Pregnancy: 

 

 Category C ; use only if benefits outweigh risks. 

 May cause neonatal withdrawal symptoms . 

 

 

 

 Lactation: 

 

 Excreted in breast milk ; use with caution due to potential effects on infant blood pressure. 

 

 

 

 Drug Interactions: 

 

 CNS depressants (e.g., alcohol, benzodiazepines) may increase sedation. 

 Beta-blockers may enhance bradycardia; caution when using together. 

 Stimulants (e.g., amphetamines) may counteract ONYDA XR’s effects. 

 Antihypertensive medications may lead to excessive blood pressure lowering.