# ProCentra ### (dextroamphetamine sulfate)
**[Full Prescribing Information](https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=1548cce2-fb6b-4f17-8a3b-868933f6c9d6&type=display)**[**DailyMed Drug Information**](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1548cce2-fb6b-4f17-8a3b-868933f6c9d6)
--- **Forms/Strengths** - **Liquid (bubblegum flavored):** 5 mg/5 mL --- ### **Dosing** - **Age:** ≥ 3 y/o - **Onset:** ~ 30 min - **Duration:** 4-6 hours - **Considerations:** Bubblegum-flavored; may be taken with or without food. Shake bottle before administering. Store at room temperature. - **Initial Dose:** - 3-5 y/o: 2.5 mg daily - 6+ y/o: 5 mg once or twice daily - **Titration:** - 3-5 y/o: 2.5 mg weekly - 6+ y/o: 5 mg weekly - **Max Dose:** - 3-5 y/o: 40 mg/day - 6+ y/o: 60 mg/day --- ### **Quick Facts** - Increases synaptic dopamine and norepinephrine via enhanced presynaptic release - Enhances focus, attention, and impulse control - Immediate-release oral solution; flexible dosing ideal for pediatric use - Unique liquid formulation for precise dosing and ease of administration - Common side effects: decreased appetite, insomnia, headache, gastrointestinal discomfort --- ### **Indications** - ADHD** (ICD-10: F90.0) - **Narcolepsy** (ICD-10: G47.419) --- ### **Off-Label Uses** - **N/A** --- ### **How to Take** - Take **once or multiple times daily**, as directed by the healthcare provider. - **Administer using the provided oral syringe** for accurate measurement—do not use household spoons. - Can be taken **with or without food**; high-fat meals may delay absorption. - Avoid taking **late in the day** to prevent insomnia. - Store securely, as it is a **controlled substance**. --- ### **Side Effects** - Common: Insomnia, decreased appetite, weight loss, abdominal pain - Serious: Cardiovascular events, psychiatric adverse reactions, growth suppression, peripheral vasculopathy --- ### **Monitoring / Labs** - **Cardiovascular**: Baseline and routine monitoring of heart rate and blood pressure. - **Growth in Pediatrics**: Regular monitoring of height and weight to detect growth suppression. - **Psychiatric Symptoms**: Observe for mood changes, anxiety, or psychosis. - **Abuse Potential**: Monitor for misuse or diversion. --- ### **Education** - **When to Call the Doctor:** - Severe **mood changes, aggression, or suicidal thoughts**. - Chest pain, rapid heartbeat, shortness of breath (**cardiovascular concerns**). - Uncontrolled movements, tics, or worsening anxiety. - Numbness, coldness, or color changes in fingers or toes (**circulatory issues**). - Unexplained weight loss or **delayed growth in pediatric patients**. - **Safety Tips:** - **Monitor blood pressure and heart rate**, especially in patients with cardiovascular risk. - Use caution in patients with **anxiety, bipolar disorder, or psychosis**, as symptoms may worsen. - Avoid **caffeine and other stimulants**, which may amplify side effects. - Ensure **adequate hydration and nutrition**, as appetite suppression is common. - **Tapering may be required** if discontinuing after long-term use. - **Parent Tips for Pediatric Patients:** - **Encourage a nutrient-dense diet** to counteract appetite suppression. - Administer in the **morning before school** for optimal effect. - Monitor **school performance and behavioral changes**. - Observe for **sleep disturbances**; adjust timing if necessary. - Communicate regularly with **teachers and caregivers** about medication effects. --- ### **Additional Information** - **Contraindications:** - **Hypersensitivity** to dextroamphetamine or formulation components. - **Use within 14 days of MAOI therapy** (risk of hypertensive crisis). - Symptomatic **cardiovascular disease, moderate-to-severe hypertension, hyperthyroidism, glaucoma**. - **History of substance use disorder**, unless benefits outweigh risks. - **Pregnancy:** - **Category C**; use only if benefits outweigh risks. - May cause **neonatal withdrawal symptoms** or **low birth weight**. - **Lactation:** - **Excreted in breast milk**; **not recommended** due to potential infant exposure. - **Drug Interactions:** - **Serotonergic drugs** (e.g., SSRIs, SNRIs, MAOIs) increase **serotonin syndrome risk**. - **Acidifying agents** (e.g., ascorbic acid) may reduce drug absorption. - **Alkalinizing agents** (e.g., sodium bicarbonate) may increase dextroamphetamine levels. - May potentiate **hypertensive effects** of certain medications (e.g., decongestants, beta-agonists).