Dyanavel XR

Forms/Strengths

Age: ≥ 6 y/o
Onset: ~60 min
Duration: up to 13 hours
Considerations: May be taken with or without food. Liquid and tablet formulations are interchangeable.
- Tablet: The 5mg dose is scored to allow for accurate dosing down to 2.5mg.
- Liquid: Bubblegum flavor
Initial Dose:
- 6-12 y/o: 2.5-5 mg
- 13+ y/o: 5-10 mg
Titration:
- 6-12 y/o: 2.5 mg every 4-7 days
- 13+ y/o: 5 mg every 4-7 days
Max Dose: 20 mg

Increases synaptic dopamine and norepinephrine; improves focus, attention, and impulse control
Extended-release oral suspension; liquid formulation for ease of administration
Unique delivery system provides consistent, sustained symptom control
Common side effects: decreased appetite, insomnia, increased heart rate, elevated blood pressure

Take once daily in the morning to reduce the risk of insomnia.
Can be taken with or without food.
Shake the suspension well before each dose to ensure even distribution.
Measure dose accurately using a provided oral syringe or dosing cup—do not use household spoons.

Cardiovascular: Baseline and routine monitoring of heart rate and blood pressure.
Growth in Pediatrics: Regular monitoring of height and weight to detect growth suppression.
Psychiatric Symptoms: Observe for mood changes, anxiety, or psychosis.
Abuse Potential: Monitor for misuse or diversion.

When to Call the Doctor:
- Severe mood changes, aggression, or suicidal thoughts.
- Chest pain, rapid heartbeat, shortness of breath (cardiovascular concerns).
- Uncontrolled movements, tics, or worsening anxiety.
- Numbness, coldness, or color changes in fingers or toes (circulatory issues).
- Unexplained weight loss or delayed growth in pediatric patients.
Safety Tips:
- Monitor blood pressure and heart rate, especially in patients with cardiovascular risk.
- Use caution in patients with anxiety, bipolar disorder, or psychosis, as symptoms may worsen.
- Avoid caffeine and other stimulants, which may amplify side effects.
- Ensure adequate hydration and nutrition, as appetite suppression is common.
- Tapering may be required if discontinuing after long-term use.
Parent Tips for Pediatric Patients:
- Encourage a nutrient-dense diet to counteract appetite suppression.
- Administer in the morning before school for optimal effect.
- Monitor school performance and behavioral changes.
- Observe for sleep disturbances; adjust timing if necessary.
- Communicate regularly with teachers and caregivers about medication effects.

Contraindications:
- Hypersensitivity to amphetamines or formulation components.
- Use within 14 days of MAOI therapy (risk of hypertensive crisis).
- Symptomatic cardiovascular disease, moderate-to-severe hypertension, hyperthyroidism, glaucoma.
- History of substance use disorder, unless benefits outweigh risks.
Pregnancy:
- Category C; use only if benefits outweigh risks.
- May cause neonatal withdrawal symptoms or low birth weight.
Lactation:
- Excreted in breast milk; not recommended due to potential infant exposure.
Drug Interactions:
- Serotonergic drugs (e.g., SSRIs, SNRIs, MAOIs) increase serotonin syndrome risk.
- Acidifying agents (e.g., ascorbic acid) may reduce drug absorption.
- Alkalinizing agents (e.g., sodium bicarbonate) may increase amphetamine levels.
- May potentiate hypertensive effects of certain medications (e.g., decongestants, beta-agonists).