ProCentra

Full Prescribing Information

DailyMed Drug Information

Forms/Strengths

Age: ≥ 3 y/o
Onset: ~ 30 min
Duration: 4-6 hours
Considerations: Bubblegum-flavored; may be taken with or without food. Shake bottle before administering. Store at room temperature.
Initial Dose:
- 3-5 y/o: 2.5 mg daily
- 6+ y/o: 5 mg once or twice daily
Titration:
- 3-5 y/o: 2.5 mg weekly
- 6+ y/o: 5 mg weekly
Max Dose:
- 3-5 y/o: 40 mg/day
- 6+ y/o: 60 mg/day

Increases synaptic dopamine and norepinephrine via enhanced presynaptic release
Enhances focus, attention, and impulse control
Immediate-release oral solution; flexible dosing ideal for pediatric use
Unique liquid formulation for precise dosing and ease of administration
Common side effects: decreased appetite, insomnia, headache, gastrointestinal discomfort

Take once or multiple times daily, as directed by the healthcare provider.
Administer using the provided oral syringe for accurate measurement—do not use household spoons.
Can be taken with or without food; high-fat meals may delay absorption.
Avoid taking late in the day to prevent insomnia.
Store securely, as it is a controlled substance.

Common: Insomnia, decreased appetite, weight loss, abdominal pain
Serious: Cardiovascular events, psychiatric adverse reactions, growth suppression, peripheral vasculopathy

Cardiovascular: Baseline and routine monitoring of heart rate and blood pressure.
Growth in Pediatrics: Regular monitoring of height and weight to detect growth suppression.
Psychiatric Symptoms: Observe for mood changes, anxiety, or psychosis.
Abuse Potential: Monitor for misuse or diversion.

When to Call the Doctor:
- Severe mood changes, aggression, or suicidal thoughts.
- Chest pain, rapid heartbeat, shortness of breath (cardiovascular concerns).
- Uncontrolled movements, tics, or worsening anxiety.
- Numbness, coldness, or color changes in fingers or toes (circulatory issues).
- Unexplained weight loss or delayed growth in pediatric patients.
Safety Tips:
- Monitor blood pressure and heart rate, especially in patients with cardiovascular risk.
- Use caution in patients with anxiety, bipolar disorder, or psychosis, as symptoms may worsen.
- Avoid caffeine and other stimulants, which may amplify side effects.
- Ensure adequate hydration and nutrition, as appetite suppression is common.
- Tapering may be required if discontinuing after long-term use.
Parent Tips for Pediatric Patients:
- Encourage a nutrient-dense diet to counteract appetite suppression.
- Administer in the morning before school for optimal effect.
- Monitor school performance and behavioral changes.
- Observe for sleep disturbances; adjust timing if necessary.
- Communicate regularly with teachers and caregivers about medication effects.

Contraindications:
- Hypersensitivity to dextroamphetamine or formulation components.
- Use within 14 days of MAOI therapy (risk of hypertensive crisis).
- Symptomatic cardiovascular disease, moderate-to-severe hypertension, hyperthyroidism, glaucoma.
- History of substance use disorder, unless benefits outweigh risks.
Pregnancy:
- Category C; use only if benefits outweigh risks.
- May cause neonatal withdrawal symptoms or low birth weight.
Lactation:
- Excreted in breast milk; not recommended due to potential infant exposure.
Drug Interactions:
- Serotonergic drugs (e.g., SSRIs, SNRIs, MAOIs) increase serotonin syndrome risk.
- Acidifying agents (e.g., ascorbic acid) may reduce drug absorption.
- Alkalinizing agents (e.g., sodium bicarbonate) may increase dextroamphetamine levels.
- May potentiate hypertensive effects of certain medications (e.g., decongestants, beta-agonists).