Adderall

Full Prescribing Information

DailyMed Drug Information

Forms/Strengths

Age: ≥ 3 y/o
Onset: 30-60 minutes
Duration: 4-6 hours
Considerations: May be taken with or without food. Administer first dose upon awakening and additional doses at intervals of 4-6 hours.
Initial Dose:
- 3-5 y/o: 2.5 mg daily
- 6+ y/o: 5 mg 1-2 times daily
Titration:
- 3-5 y/o: 2.5 mg weekly
- 6+ y/o: 5 mg weekly
Max Dose:
- ≤50 kg: 40 mg/day
- >50 kg: 60 mg/day (Narcolepsy)

Increases synaptic norepinephrine/dopamine by stimulating presynaptic release and inhibiting reuptake
Enhances focus, attention, and impulse control
Side effects: decreased appetite, insomnia, elevated blood pressure
Immediate release formulation for rapid onset
Unique amphetamine salt blend; monitor cardiovascular status; caution with MAO inhibitors

Depression (ICD-10: F33.9): Occasionally used adjunctively in treatment-resistant cases.
Cognitive Disorders in TBI: May be prescribed to improve attention and concentration.

Administer once or multiple times daily, as directed.
Take with or without food; high-fat meals may delay absorption.
If using the tablet, swallow whole; do not crush, chew, or split unless scored.
Avoid dosing late in the day to prevent insomnia.

Cardiovascular: Baseline and routine monitoring of heart rate and blood pressure.
Growth in Pediatrics: Regular monitoring of height and weight to detect growth suppression.
Psychiatric Symptoms: Observe for mood changes, anxiety, or psychosis.
Abuse Potential: Monitor for misuse or diversion.

When to Call the Doctor:
- Severe mood changes, aggression, or suicidal thoughts.
- Chest pain, shortness of breath, or palpitations (cardiovascular concerns).
- Uncontrolled movements, tics, or worsening anxiety.
- Signs of circulatory issues (e.g., numbness, coldness, or color changes in fingers/toes).
- Unexplained weight loss or growth suppression in pediatric patients.
Safety Tips:
- Monitor blood pressure and heart rate regularly, especially in patients with cardiovascular risk.
- Use caution in patients with history of anxiety, bipolar disorder, or psychosis, as symptoms may worsen.
- Avoid caffeine and other stimulants, which may increase side effects.
- Ensure adequate hydration and nutrition, as appetite suppression is common.
- Do not abruptly discontinue; tapering may be needed in long-term users.
Parent Tips for Pediatric Patients:
- Encourage a high-calorie diet to offset appetite suppression.
- Monitor school performance and behavioral changes.
- Administer the first dose before school for optimal effect.
- Observe for sleep disturbances and adjust dosing schedule if needed.
- Keep communication open with teachers and caregivers regarding medication effects.

Contraindications:
- Hypersensitivity to amphetamines or any formulation components.
- Use within 14 days of MAOI therapy (risk of hypertensive crisis).
- Symptomatic cardiovascular disease, moderate-to-severe hypertension, hyperthyroidism, glaucoma.
- History of substance use disorder, unless benefits outweigh risks.
Pregnancy:
- Category C; use only if benefits outweigh risks.
- May cause neonatal withdrawal symptoms or low birth weight.
Lactation:
- Excreted in breast milk; not recommended due to potential infant exposure.
Drug Interactions:
- Serotonergic drugs (e.g., SSRIs, SNRIs, MAOIs) increase serotonin syndrome risk.
- Acidifying agents (e.g., ascorbic acid) may reduce drug absorption.
- Alkalinizing agents (e.g., sodium bicarbonate) may increase amphetamine levels.
- May potentiate hypertensive effects of certain medications (e.g., decongestants, beta-agonists).